Prevalence of MRSA Genes in Kurdistan Region: Systematic Review
DOI:
https://doi.org/10.23918/eajse.v10i3p12Keywords:
MRSA, Kurdistan, mecAAbstract
Antibiotic resistance, particularly Methicillin-resistant Staphylococcus aureus (MRSA) is a trending global threat associated with severe infections and high morbidity and mortality rates. This study was carried out to systematically review the prevalence and distribution of MRSA in the Kurdistan region. A comprehensive search identified 244 studies, but only 14 meeting the inclusion criteria. Studies from Zakho, Duhok, Erbil, Sulaimani, and Kirkuk revealed varying MRSA rates, with high rates among urinary tract patients, diabetic foot patients, and healthcare workers. The genetic analysis highlighted the presence of the mecA gene as a predominant resistant gene. The distribution of MRSA was unequal, as Duhok had the highest incidence. These findings emphasize the urgent need for intervention and surveillance strategies to overcome this combat with MRSA and antibiotic resistance in the Kurdistan region.
References
Jalal Ahmed H, H Ibrahim A, S Al-Rawi S, R Ganjo A, Fryad Saber H. Molecular Characterization of Carbapenem resistant Escherichia coli and Klebsiella pneumoniae in Erbil, Iraq. Journal of Population Therapeutics and Clinical Pharmacology. 2023;30(4):457-63.https://doi.org/10.47750/jptcp.2023.30.04.044.
[2] Gajdács M. The continuing threat of methicillin-resistant Staphylococcus aureus. Antibiotics. 2019;8(2):52.https://doi.org/10.3390/antibiotics8020052.
[3] Bilyk BL, Panchal VV, Tinajero-Trejo M, Hobbs JK, Foster SJ. An interplay of multiple positive and negative factors governs methicillin resistance in Staphylococcus aureus. Microbiology and Molecular Biology Reviews. 2022;86(2):e00159-21.https://doi.org/10.1128/mmbr.00159-21.
[4] Tsouklidis N, Kumar R, Heindl SE, Soni R, Khan S. Understanding the fight against resistance: hospital-acquired methicillin-resistant Staphylococcus aureus vs. community-acquired methicillin-resistant Staphylococcus aureus. Cureus. 2020;12(6).https://doi.org/10.7759/cureus.8867.
[5] Hasanpour AH, Sepidarkish M, Mollalo A, Ardekani A, Almukhtar M, Mechaal A, et al. The global prevalence of methicillin-resistant Staphylococcus aureus colonization in residents of elderly care centers: a systematic review and meta-analysis. Antimicrobial Resistance & Infection Control. 2023;12(1):4.https://doi.org/10.1186/s13756-023-01210-6.
[6] Giulieri SG, Guérillot R, Kwong JC, Monk IR, Hayes AS, Daniel D, et al. Comprehensive genomic investigation of adaptive mutations driving the low-level oxacillin resistance phenotype in Staphylococcus aureus. MBio. 2020;11(6):10.1128/mbio. 02882-20.https://doi.org/10.1128/mbio.02882-20.
[7] Alghamdi BA, Al-Johani I, Al-Shamrani JM, Alshamrani HM, Al-Otaibi BG, Almazmomi K, et al. Antimicrobial resistance in methicillin-resistant Staphylococcus aureus. Saudi journal of biological sciences. 2023;30(4):103604.https://doi.org/10.1016/j.sjbs.2023.103604.
[8] Hami IA, Ibrahim KS. Incidence of methicillin-resistant Staphylococcus aureus (MRSA) recovered from patients with urinary tract infections in zakho city/kurdistan-Iraq. Science Journal of University of Zakho. 2023;11(1):91-7. https://doi.org/10.25271/sjuoz.2023.11.1.1041.
[9] Hussein NR, Basharat Z, Muhammed AH, Al-Dabbagh SA. Comparative evaluation of MRSA nasal colonization epidemiology in the urban and rural secondary school community of Kurdistan, Iraq. PLoS One. 2015;10(5):e0124920. https://doi.org/10.1371/journal.pone.0124920.
[10] Hussein NR, Alyas A, Majeed M, Assafi MS. Prevalence rate and prevalent genotypes of ca-mrsa in kurdistan region: First report from iraq. International Journal of Pure and Applied Sciences and Technology. 2015;27(1):44. https://doi.org/10.17795/iji-35375.
[11] Abdulkareem WL, Hussein NR, Mohammed AA, Arif SH, Naqid IA. Risk Factors Association for MRSA Nasal Colonization in Preoperative Patients in Azadi Teaching Hospital-Duhok, Kurdistan Region, Iraq. Science Journal of University of Zakho. 2020;8(3):88-91. https://doi.org/10.25271/sjuoz.2020.8.3.712.
[12] Hami I, IBRAHIM K. The prevalence and antibiotic resistance methicillin-resistant Staphylococcus aureus (MRSA) recovered from adult Urinary tract infections in Zakho City, Kurdistan-Iraq. 2022. https://doi.org/10.3390/eca2022-12740.
[13] Hussein N, Salih RS, Rasheed NA. Prevalence of methicillin-resistant Staphylococcus aureus in hospitals and community in Duhok, Kurdistan region of Iraq. International Journal of Infection. 2019;6(2). https://doi.org/10.5812/iji.89636.
[14] Anwar K, Hussein D, Salih J. Antimicrobial susceptibility testing and phenotypic detection of MRSA isolated from diabetic foot infection. International Journal of General Medicine
2020:1349-57.https://doi.org/10.2147/IJGM.S278574.
[15] Hallabjaiy RM, Darogha SN, Hamad PA. Vancomycin resistance among methicillin-resistant Staphylococcus aureus isolated from clinical samples in Erbil city-Iraq. Medical Journal of Islamic World Academy of Sciences. 2014;22(4):168-74.http://dx.doi.org/10.32894/kujss.2017.124949.
[16] A Ali F, Aziz Sabah H, Abdulrahman Khalis N, Rzgar Hussien P, Muhanad Ghanim S. Impact the Antibiotic Resistance for Staphylococcus aureus in Hospitalized Cancer Patients in Erbil Governate, Iraq. South Asian Journal of Research in Microbiology. 2022;14(3):12-23.https://doi.org/10.9734/sajrm/2022/v14i3272.
[17] Taha AB, Al-Salihi SMS. Compared Antibiotic Resistance Patterns of Methicillin-Resistant Staphylococcus aureus and Methicillin-Sensitive Staphylococcus aureus. Impact of a health educational program on knowledge of female nursing staff and students regarding breast Cancer prevention and early detection in Erbil city.77. https://doi.org/10.2144%2Ffsoa-2019-0122.
[18] AL-Salihi SS, Karim GF, Al-Bayati A, Obaid HM. Prevalence of Methicillin-Resistant and Methicillin Sensitive Staphylococcus aureus Nasal Carriage and their Antibiotic Resistant Patterns in Kirkuk City, Iraq. Journal of Pure & Applied Microbiology. 2023;17(1). https://doi.org/10.22207/JPAM.17.1.22.
[19] Mohammed RQ, Khalid HM, Mero WMS. Prevalence and molecular analysis of virulence genes of Methicillin-resistant Staphylococcus aureus colonized among inpatients in hospitals of Duhok Province, Iraq. Journal of Wildlife and Biodiversity. 2023;7(Special Issue):780-96. https://doi.org/10.5281/zenodo.10385670.
[20] YASSIN NA. NASAL CARRIAGE OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS) MRSA) AMONG MEDICAL AND NON-MEDICAL STUDENTS OF SHEIKHAN-POLYTECHNIQUE COLLEGE AND TECHNICAL INSTITUTE, IRAQ. Journal of Duhok University. 2022;25(2):291-9. https://doi.org/10.26682/sjuod.2022.25.2.27.
[21] Hussein NR, Assafi MS, Ijaz T. Methicillin-resistant Staphylococcus aureus nasal colonisation amongst healthcare workers in Kurdistan Region, Iraq. Journal of global antimicrobial resistance. 2017;9:78-81. https://doi.org/10.1016/j.jgar.2017.01.010.
[22] Al-Mayahi A, Srhan F. A preliminary study of Aminoglycoside Modifying Enzymes (AMEs) of Multiple Antibiotic Resistance of Methicillin-resistant Staphylococcus aureus (MRSA) isolated from clinical specimens in Al-Diwaniya/Iraq. Jordan Journal of Biological Sciences. 2021;14(4). https://doi.org/10.54319/jjbs/140414.
[23] Ahmed ON, Mahdi NB, Altaii HA. Molecular detection of VRSA and MRSA strains in some infections in nineveh hospitals, Iraq. Biochemical & Cellular Archives. 2021;21(1)
[24] Aksu B, Yağcı A, İlki A, Söyletir G. Molecular epidemiology of MRSA isolates in the intensive care unit during a 4-year-period. Marmara Medical Journal. 2002;15(3):151-4
[25] Askari E, Soleymani F, Arianpoor A, Tabatabai SM, Amini A, NaderiNasab M. Epidemiology of mecA-methicillin resistant Staphylococcus aureus (MRSA) in Iran: a systematic review and meta-analysis. Iranian journal of basic medical sciences. 2012;15(5):1010. https://doi.org/10.22038/IJBMS.2012.4907.
[26] Ali S, Assafi M. Prevalence and antibiogram of Pseudomonas aeruginosa and Staphylococcus aureus clinical isolates from burns and wounds in Duhok City, Iraq. J Infect Dev Ctries. 2024;18(1):82-92. https://doi.org/10.3855/jidc.18193.
[27] Rasheed NA, Hussein NR. Methicillin-resistant Staphylococcus aureus carriage rate and molecular characterization of the staphylococcal cassette chromosome mec among Syrian
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