Evaluation of Genotoxic effects of a Hydro-alcoholic extract of flowers of Nargis (Narcissus Tazetta L.)
DOI:
https://doi.org/10.23918/eajse.v7i2p39Keywords:
Hydroalcoholic Extract, Narcissus Tazetta L., Breast Carcinoma, ApoptoticAbstract
The goal of this study was to determine the genotoxic potential of a hydroalcoholic extract of Nargis flowers (Narcissus Tazetta L.). The genotoxicity potential of standardized hydroalcoholic extract of Narcissus Tazetta L at different concentrations was assessed using human breast cancer cells applying the MTT test for cell cytotoxicity. In control cells, Nargis flowers extract did not totally break DNA, however, flowers-treated cells showed high amounts of damage in a dose-dependent way. According to the findings, the crude hydroalcoholic extract of Narcissus Tazetta (Nargis flowers) had a potent inhibitory effect on human breast carcinoma cancer cell proliferation, which was mediated by its pro-apoptotic antiproliferative activity.
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