Volume 8 Issue 3 Article 9

Formulation and Evaluation of Cefotaxime Sodium Loaded Emulgel for Topical Bacterial Infections

Authors: Esra Tariq Anwer1 & Omji Porwal2 & Sharad Visht3 & Sachin Kumar Singh4 & Amit Singh5 & Neeraj Kumar Fuloria 6 & Nitin Chitranshi 7 & Dinesh Kumar Patel 8
1Department of Pharmaceutics, Faculty of Pharmacy, Tishk International University, Erbil, Iraq
2Department of Pharmaceutics, Faculty of Pharmacy, Tishk International University, Erbil, Iraq
3Department of Pharmaceutics, Faculty of Pharmacy, Tishk International University, Erbil, Iraq
4School of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144411, India
4Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia
5Department of Pharmacy, School of Medical & Allied Sciences, Galgotias University, Uttar Pradesh, Greater Noida, 201310, India
6Faculty of Pharmacy, AIMST University, Bedong 08100, Kedah, Malaysia
6Centre of Excellence for Biomaterials Engineering, AIMST University, Bedong 08100, Kedah, Malaysia
7Faculty of Medicine and Health Sciences, Macquarie University, F10A, 2 Technology Place, North Ryde, NSW 2109, Australia
8Faculty of Health Science, Shalom Institute of Health and Allied Sciences Sam Higginbottom University of Agriculture, Technology and Sciences (SHUATS)-State University (Formerly Allahabad Agriculture Institute) Naini, Allahabad, India

Abstract: The bacterial infections are very common and become a serious issue like in case of infections of one and more reproductive organ, inflammation on protective membrane of brain and spinal cord, inflammation of lungs air sacs, body drainage system infections, problem in body’s extreme response and infection caused by sexually transmitted bacteria in male and female. Generally, these bacterial infections are treated by using antibiotics like cefotaxime that is a semisynthetic, β-lactamase resistant, third-generation broad-spectrum cephalosporin. The common side effects of cefotaxime are uneasiness of stomach before vomiting, sneezing, itching.
The topical antibacterial dosage forms like creams, gel, and ointment have some demerits and low duration of drug release. The emulgel is an alternative for topical drug delivery with several merits like enhanced skin penetration and improved bioavailability, reduced dosing, improved patient acceptability with targeted drug delivery, freedom of termination of the therapy at any time, drug delivery in controlled fashion for prolong duration.
The aim of study was to develop a biphasic promising drug delivery system emulgel of cefotaxime. The 23 experimental design was used to prepare various emulgel batches to determinant the effect of liquid paraffin, span 20 and tween 20 on the performance of emulgel. The Batch F1 showed the maximum drug release while batch F8 up to 240 minutes. The drug release kinetics study of Batch F8 showed the Higuchi-Matrix as a best fit model and the Fickian Diffusion as a mechanism of drug release with R2 value 0.9158 and K value 8.4741.

Keywords: Antibiotics, Carbopol, Cefotaxime, Cephalosporin, Emulgel, Topical, Delivery

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Doi: 10.23918/eajse.v8i3p105

Published: December 21, 2022

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