1. Home
  2. 2023-V9-I2
  3. Innovations in Formulation and Evaluation of Oral Fast Dissolving Film
Statistics

Article Views: 379

PDF Downloads: 94

  • Date of Publication : 2023-06-20 Article Type : Research Article
  • Innovations in Formulation and Evaluation of Oral Fast Dissolving Film

    Rozhan Arif Muhammed ¹*,  Zainab Yalman², Bushra Rashid Noaman³, Sharad Visht ¹, Sarmad Jabbar ¹, and Sana Sirwan Salih ¹

    Affiliation

    ¹ Faculty of Pharmacy, Tishk International University, Erbil KRG, Iraq
    ² Basic Sciences Department, Faculty of Dentistry, Tishk International University Erbil, Iraq
    ³ Pedodontic Department, Faculty of Dentistry, Tishk International University, Erbil, KRG, Iraq
    * Corresponding Author


    ORCID :

    Rozhan Arif: https://orcid.org/0000-0003-1117-8325Zainab Yalman: https://orcid.org/0000-0001-9098-1583Bushra Rashid: https://orcid.org/0000-0003-3500-9729Sharad Visht: https://orcid.org/0000-0002-9370-3770Sana Sirwan : https://orcid.org/0000-0001-9509-8466


    DOI :

    https://doi.org/10.23918/eajse.v9i2p9


    Article History

    Received: 2023-01-30

    Revised: 2023-04-25

    Accepted: 2023-06-08

    Abstract

    The most popular and convenient route for the drug administration is oral route with some merits, demerits, and limitations with some paediatric and geriatrics patients as they face difficulty to  take solid dosage forms like capsules or compressed tablets that results in improper dosing due to vomit or removal of drug from buccal cavity. Oral fast dissolving films are a good alternate to overcome these difficulties and to deliver the drugs with any these age groups. Fast dissolving oral films are capable of delivering the drug locally and systemically by absorption through buccal mucosa, sublingual route, and oesophagus and finally form the stomach. Oral fast dissolving films offers a convenient way of dosing medication, not only for special groups of the population like paediatric, geriatric, confined to bed patients, patients with mental problems, but also to the general population. The present article review is focused on composition, preparation methods, evaluation and advancements of orally fast dissolving oral films.

    Keywords :

    Oral Fast Dissolving Films; Disintegrating; Hydrophilic; Polymers; Oral; Buccal; Solvent Casting


    [1]    Bhyan B, Jangra S, Kaur M, Singh H. Orally fast dissolving films: innovations in formulation and technology. Int J Pharm Sci Rev Res. 2011 Jul; 9(2): 9-15.       
    Google Scholar

    [2]    Bala R, Pawar P, Khanna S, Arora S. Orally dissolving strips: A new approach to oral drug delivery system. International journal of pharmaceutical investigation. 2013 Apr; 3(2): 67. https://doi.org/10.4103/2230-973X.114897
    Google Scholar

    [3]    Irfan M, Rabel S, Bukhtar Q, Qadir MI, Jabeen F, Khan A. Orally disintegrating films: A modern expansion in drug delivery system. Saudi pharmaceutical journal. 2016 Sep 1; 24(5): 537-46. https://doi.org/10.1016/j.jsps.2015.02.024
    Google Scholar

    [4]    Dinge A, Nagarsenker M. Formulation and evaluation of fast dissolving films for delivery of triclosan to the oral cavity. Aaps Pharmscitech. 2008 Jun; 9: 349-56. https://doi.org/10.1208/s12249-008-9047-7
    Google Scholar

    [5]    Birla N, Mandloi K, Mandloi R, Pillai S. Formulation and evaluation of quick dissolving films of promethazine hydrochloride. Research Journal of Pharmacy and Technology. 2017; 10(4): 1025-8. https://doi.org/10.5958/0974-360X.2017.00185.8
    Google Scholar

    [6]    Mahaparale MA, Shivnikar SS, Pawar KV, Prashant N. Fast dissolving oral films: An innovative drug delivery system. IJRRPAS. 2012; 2(3): 482-96.
    Google Scholar

    [7]    Juluru NS. Fast dissolving oral films: A review. IJAPBC. 2013 Jan; 2(1): 108-12.
    Google Scholar

    [8]    Mandeep, K., Rana, A., & Nimrata, S. Fast Dissolving Films: An Innovative Drug Delivery System. International Journal of Pharmaceutical Research & Allied Sciences. 2013; 2(1). 
    Google Scholar

    [9]    Siddiqui MN, Garg G, Sharma PK. A short review on “A novel approach in oral fast dissolving drug delivery system and their patents”. Adv Biol Res. 2011 Nov; 5(6): 291-303.
    Google Scholar

    [10]    Desu PK, Brahmaiah B, Nagalakshmi A, Neelima K, Nama S, Baburao C. An overview on rapid dissolving films. Asian J. Pharm. Res. 2013; 3(1): 15-23.
    Google Scholar

    [11]    Dixit RP, Puthli SP. Oral strip technology: Overview and future potential. Journal of controlled release. 2009 Oct 15; 139(2): 94-107. https://doi.org/10.1016/j.jconrel.2009.06.014
    Google Scholar

    [12]    Ghodake PP, Karande KM, Osmani RA, Bhosale RR, Harkare BR, Kale BB. Mouth dissolving films: Innovative vehicle for oral drug delivery. polymer. 2013; 9: 20.
    Google Scholar

    [13]    Kalyan S, Bansal M. Recent trends in the development of oral dissolving film. Int J PharmTech Res. 2012 Apr; 4(2): 725-33.
    Google Scholar

    [14]    Kushwaha V, Akhtar J, Usmani S, Singh SP. A review on fast dissolving formulation technologies. World Journal of Pharmacy and Pharmaceutical Sciences. 2015 May 10; 4(7): 574-85.
    Google Scholar

    [15]    Muhammed RA, Omer HK. Formulation and Evaluation of Fast Dissolving Oral Film of Imipramine. Polytechnic Journal. 2020 Jun 30; 10(1): 182-8. https://doi.org/10.25156/ptj.v10n1y2020.pp182-188
    Google Scholar

    [16]    Keshari A, Sharma PK, Parvez N. Fast dissolving oral film: a novel and innovative drug delivery system. International Journal of Pharma Sciences and Research. 2014; 5(3): 92-5.
    Google Scholar

    [17]    Nagar P, Chauhan I, Yasir M. Insights into Polymers: Film Formers in Mouth Dissolving Films. Drug invention today. 2011 Dec 1; 3(12).
    Google Scholar

    [18]    Fulzele SV, Satturwar PM, Dorle AK. Polymerized rosin: novel film forming polymer for drug delivery. International journal of pharmaceutics. 2002 Dec 5; 249(1-2): 175-84. https://doi.org/10.1016/s0378-5173(02)00529-x
    Google Scholar

    [19]    Patel VM, Prajapati BG, Patel MM. Effect of hydrophilic polymers on buccoadhesive Eudragit patches of propranolol hydrochloride using factorial design. Aaps Pharmscitech. 2007 Jun; 8: E119-26. https://doi.org/10.1208/pt0802045
    Google Scholar

    [20]    Parmar D, Patel U, Bhimani B, Tripathi A, Daslaniya D, Patel G. Orally fast dissolving films as dominant dosage form for quick release. Int J Pharm Res Bio-Sci. 2012; 1(3): 27-41.
    Google Scholar

    [21]    Rédai EM, Antonoaea P, Todoran N, Vlad RA, Bîrsan M, Tătaru A, Ciurba A. Development and evaluation of fluoxetine fast dissolving films: an alternative for noncompliance in pediatric patients. Processes. 2021 Apr 28; 9(5): 778. https://doi.org/10.3390/pr9050778
    Google Scholar

    [22]    Choudhary DR, Patel VA, Chhalotiya UK, Patel HV, Kundawala AJ. Formulation and evaluation of fast dissolving film of levocetirizine dihydrochloride using different grades of methocel. Journal of Pharmacy Research. 2011 Sep; 4(9): 2919-24. https://doi.org/10.4103/2230-973X.82417
    Google Scholar

    [23]    Prasanthi NL, Krishna CS, Gupta ME, Manikiran S, Rao NR. Design and development of sublingual fast dissolving films for an antiasthmatic drug. Der pharmacia lettre. 2011; 3(1): 382-95.
    Google Scholar

    [24]    Mahajan A, Chhabra N, Aggarwal G. Formulation and characterization of fast dissolving buccal films: A review. Der Pharm. Lett. 2011; 3(1): 152-65.
    Google Scholar

    [25]    Saini P, Kumar A, Sharma P, Visht S. Fast disintegrating oral films: A recent trend of drug delivery. Int J Drug Dev Res. 2012 Oct; 4(4): 80-94. https://doi.org/10.1007/s12272-012-1215-3
    Google Scholar

    [26]    Cilurzo F, Minghetti P, Como A, Montanari L. Feasibility study of fast-dissolving film containing Piroxicam. THE AAPS JOURNAL. 2005; 7(S2): W4148-. https://doi.org/10.1208/s12249-010-9525-6
    Google Scholar

    [27]    Khatoon N, Rao NR, Reddy BM. Overview on fast dissolving oral films. International journal of Chemistry and Pharmaceutical sciences. 2013; 1(1): 63-75.
    Google Scholar

    [28]    Kumar R, Sulochana M. Fast dissolving films: a unique strategy for drug delivery. Asian J Pharm Res. 2014; 4(1): 47-55.
    Google Scholar

    [29]    Choudhary DR, Patel VA, Chhalotiya UK, Patel HV, Kundawala AJ. Development and characterization of pharmacokinetic parameters of fast-dissolving films containing levocetirizine. Scientia pharmaceutica. 2012 Sep; 80(3): 779-88. https://doi.org/10.3797/scipharm.1205-15 
    Google Scholar

    [30]    Thakur RR, Rathore DS, Narwal S. Orally disintegrating preparations: recent advancement in formulation and technology. Journal of Drug Delivery and Therapeutics. 2012 May 14; 2(3). https://doi.org/10.22270/jddt.v2i3.130
    Google Scholar

    [31]    El-Setouhy DA, El-Malak NS. Formulation of a novel tianeptine sodium orodispersible film. Aaps Pharmscitech. 2010 Sep; 11: 1018-25. https://doi.org/10.1208/s12249-010-9464-2
    Google Scholar

    [32]    Panda BP, Dey NS, Rao ME. Development of innovative orally fast disintegrating film dosage forms: a review. International Journal of Pharmaceutical Sciences and Nanotechnology. 2012 Jul; 5(2): 1666-74. https://doi.org/10.37285/ijpsn.2012.5.2.2
    Google Scholar

    [33]    ElMeshad AN, El Hagrasy AS. Characterization and optimization of orodispersible mosapride film formulations. Aaps Pharmscitech. 2011 Dec; 12: 1384-92. https://doi.org/10.1208/s12249-011-9713-z
    Google Scholar

    [34]    Murata Y, Isobe T, Kofuji K, Nishida N, Kamaguchi R. Preparation of fast dissolving films for oral dosage from natural polysaccharides. Materials. 2010 Aug 9; 3(8): 4291-9. https://doi.org/10.3390/ma3084291
    Google Scholar

    [35]    Satyanarayana DA, Keshavarao KP. Fast disintegrating films containing anastrozole as a dosage form for dysphagia patients. Archives of pharmacal research. 2012 Dec; 35: 2171-82. 
    Google Scholar

    [36]    Morris KR, Rodriguez-Hornedo N. Encyclopedia of pharmaceutical technology. Swarbrick J, Boylan J, editorsMarcel Dekker. 1993: 393-440. 
    Google Scholar

    [37]    Arya A, Chandra A, Sharma V, Pathak K. Fast dissolving oral films: an innovative drug delivery system and dosage form. International Journal of ChemTech Research. 2010 Jan; 2(1): 576-83.
    Google Scholar

    [38]    Saurabh R, Malviya R, Sharma PK. Trends in buccal film: Formulation characteristics, recent studies and patents. Eur J Appl Sci. 2011; 3: 93-101.
    Google Scholar

    [39]    Gole DJ, Levinson RS, Wilkinson PK, Davies JD, inventors; Janssen Pharmaceutica Inc, assignee. Pharmaceutical and other dosage forms. United States patent US 5,648,093. 1997 Jul 15.
    Google Scholar

    [40]    Frey P. Film strips and pharmaceuticals. Pharma. Mfg. & Packag. Sourcer, winter. 2006; 92.

    [41]    Sharma D, Kaur D, Verma S, Singh D, Singh M, Singh G, & Garg R. Fast dissolving oral films technology: A recent trend for an innovative oral drug delivery system. International Journal of Drug Delivery. 2015; 7(2): 60-75. 
    Google Scholar

    [42]    Venkata A, Shireesh MR, Kiran P. A review on oral thin fast dissolving films; recent trends of dosage form for quick release. Int J Pharm Bio Sci. 2014; 5(4): 54-67.
    Google Scholar

    [43]    Patel J, Patel KR, Patel NM. Review on fast dissolving film. Int J Advanced Pharmaceut. 2013; 3(1): 44-50.
    Google Scholar

    [44]    Arya A, Chandra A, Sharma V, Pathak K. Fast dissolving oral films: an innovative drug delivery system and dosage form. International Journal of ChemTech Research. 2010 Jan; 2(1): 576-83.
    Google Scholar

    [45]    Felton LA, O’Donnell PB, McGinity JW. Mechanical properties of polymeric films prepared from aqueous dispersions. InAqueous polymeric coatings for pharmaceutical dosage forms. 2008 Jan 9; 125-148: CRC Press.
    Google Scholar

    [46]    Smriti T. Mouth dissolving films: A review. Int. J. Pharma Bio. Sci. 2013 Jan; 4: 899-908.
    Google Scholar

    [47]    Ahmed MG, Charyulu RN, Harish NM, Prabhu P. Formulation and in-vitro evaluation of Chitosan films containing tetracycline for the treatment of periodontitis. Asian Journal of Pharmaceutics (AJP). 2009; 3(2). https://doi.org/10.22377/ajp.v3i2.251 
    Google Scholar

    [48]    Shinde AJ, Garala KC, More HN. Development and characterization of transdermal therapeutics system of tramadol hydrochloride. Asian Journal of Pharmaceutics (AJP). 2008; 2(4).
    Google Scholar

    [49]    Mashru RC, Sutariya VB, Sankalia MG, Parikh PP. Development and evaluation of fast-dissolving film of salbutamol sulphate. Drug development and industrial pharmacy. 2005 Jan 1; 31(1): 25-34. https://doi.org/10.1081/ddc-43947
    Google Scholar

    [50]    Jayjock E, Schmitt R, Chein C, Tirol G. Determination of fast dissolve oral film dissolution rate via conductivity. Dow Chemical Company. 2005: 1-4. 
    Google Scholar

    [51]    Gauri S, & Kumar G. Fast dissolving drug delivery and its technologies. The pharma innovation. 2012; 1(2, Part A): 34. 
    Google Scholar

    [52]    Nishimura M, Matsuura K, Tsukioka T, Yamashita H, Inagaki N, Sugiyama T, Itoh Y. In vitro and in vivo characteristics of prochlorperazine oral disintegrating film. International journal of pharmaceutics. 2009 Feb 23; 368(1-2): 98-102. https://doi.org/10.1016/j.ijpharm.2008.10.002
    Google Scholar



    @article{muhammed,rozhanarifandyalman,zainabandnoaman,bushrarashidandvisht,sharadandjabbar,sarmadandsalih,sanasirwan2023,
     author = {Muhammed, Rozhan Arif and  Yalman, Zainab  and Noaman, Bushra Rashid and Visht, Sharad and Jabbar, Sarmad  and Salih, Sana Sirwan},
     title = {Innovations in Formulation and Evaluation of Oral Fast Dissolving Film},
     journal = {Eurasian J. Sci. Eng},
     volume = {9},
     number = {2},
     pages = {115-130},
     year = {2023}
    }
    Copy

    Muhammed, R. A., Yalman, Z., Noaman, B. R., Visht, S., Jabbar, S., & Salih, S. S. (2023). Innovations in Formulation and Evaluation of Oral Fast Dissolving Film. Eurasian J. Sci. Eng, 9(2),115-130.

    Copy

    Muhammed, RA, Yalman, Z, Noaman, BR, Visht, S, Jabbar, S, and Salih, SS. "Innovations in Formulation and Evaluation of Oral Fast Dissolving Film." Eurasian J. Sci. Eng, 9.2, (2023), pp.115-130.

    Copy

    Muhammed, R.A., Yalman, Z., Noaman, B.R., Visht, S., Jabbar, S. and Salih, S.S. (2023) "Innovations in Formulation and Evaluation of Oral Fast Dissolving Film", Eurasian J. Sci. Eng, 9(2), pp.115-130.

    Copy

    Muhammed RA, Yalman Z, Noaman BR, Visht S, Jabbar S, Salih SS. Innovations in Formulation and Evaluation of Oral Fast Dissolving Film. Eurasian J. Sci. Eng. 2023; 9(2):115-130.

    Copy

    Under Development

    Under Development

    Under Development

  • Innovations in Formulation and Evaluation of Oral Fast Dissolving Film