Approaches to isolating the base have become a crucial element in enhancing quality stability during a seismic earthquake load. In the present day, base detachment is routinely utilized as an essential arrangement technique for structures and frameworks in seismically active zones. This paper aims towards the dynamic analysis of a multi-story RCC building with various parameters. For the sake of study and verification, a model of a ten-story RCC building with a symmetrical floor plan is considered. The study was conducted using SAP 2000's time-history-based software. In this paper,72 models were studied based on various parameters such as bay width, number of bays, number of floors, and various isolators (Lead Rubber Bearings, Friction Pendulum Bearing, Fixed, and Hinge). The reaction of the structure, for example, time period, base shear, and story displacements are studied and a comparison is made. The paper showed the clear superiority of isolation methods in resisting earthquakes. The friction pendulum support has been the preferred type due to the lowest drift story of the building when it was compared with other support systems. Also, as the results showed a high time period when using the lead rubber bearings, which shows the model's ability to withstand earthquakes.