Evaluation of Genotoxic effects of a Hydro-alcoholic extract of flowers of Nargis (Narcissus Tazetta L.)

Authors: Subasini Uthirapathy1 & Amani Tahsin2
1Department of Pharmacology, Faculty of Pharmacy, Tishk International University, Erbil, Iraq
2Department of Pharmaceutical Basic Sciences, Faculty of Pharmacy, Tishk International University, Erbil, Iraq

Abstract: The goal of this study was to determine the genotoxic potential of a hydroalcoholic extract of Nargis flowers (Narcissus Tazetta L.). The genotoxicity potential of standardized hydroalcoholic extract of Narcissus Tazetta L at different concentrations was assessed using human breast cancer cells applying the MTT test for cell cytotoxicity. In control cells, Nargis flowers extract did not totally break DNA, however, flowers-treated cells showed high amounts of damage in a dose-dependent way. According to the findings, the crude hydroalcoholic extract of Narcissus Tazetta (Nargis flowers) had a potent inhibitory effect on human breast carcinoma cancer cell proliferation, which was mediated by its pro-apoptotic antiproliferative activity.

Keywords: Hydroalcoholic Extract, Narcissus Tazetta L., Breast Carcinoma, Apoptotic

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Doi: 10.23918/eajse.v7i2p39

Published: December 21, 2021

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