Synthesis, Antimicrobial, DPPH Radical Scavenging Assays and Molecular Docking Study of New Series N-Phenylpyrazoline Derivatives

Author: Media Noori Abdullah1
1Chemistry Department, College of Science, Salahaddin University, Erbil, Iraq

Abstract: New candidates of N-phenylpyrazoline derivatives were designed combining the Indole moiety to explore its potential as antimicrobial and antioxidant activity. The starting material synthesis was achieved through One-pot three-component reaction; at that point, it was acylated and interacted with various substituted benzaldehydes to result in new chalcones that were later cyclized to N-phenylpyrazoline, through reaction with phenyl hydrazine. The structures of the synthesized compounds were reinforced by their spectral data. The final compounds were screened for antibacterial activity against resistant strains of Staphylococcus aureus and Escherichia coli microorganisms; as a result, it showed that the compounds with methoxy group at position meta and hydroxy at position ortho were the highly active derivatives. Meanwhile, the highly active compound with antifungal activity against C. Albicans, had nitro group at para position. During the evaluation of proton donating antioxidant activity, using DPPH radical scavenging assays method; it was exposed that, the derivatives with highly active antibacterial had the most antioxidant activity. In the final step, the molecular docking study exposed that the compound with highly active antibacterial and antioxidant activity was the most potent derivative. The resulting studies disclosed that the synthesized N-phenylpyrazoline derivatives displayed less specificity than the reference compounds.

Keywords: One Pot Reaction, Chalcone, N-Phenylpyrazoline, Antimicrobial, Dpph Scavenging Activity, Molecular Docking Study

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doi: 10.23918/eajse.v7i1p1

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