4,4’-bis-[4-(substituted-phenyl)-1-azetidinyl-2-one]-biphenyl Via an Improved Procedure Using Zn-Cu Couple in Sonic Reformatsky Reaction

Authors: Faiq H.S. Hussain1 & Lana H.R. Al-Chawshili1  
1TIU-Research Center, Tishk International University, Erbil, Iraq
2Chemistry Department, College of Education, University of Salahaddin, Erbil, Iraq

Abstract:Considerable interest has been focused on azetidinone (β-lactam) compounds for their broad spectrum antimicrobial activity. Therefore, a new series of bis-azetidinone compounds (5a-l) have been synthesized via the reaction of new Schiff bases (3a-l) with ethylbromoacetate and Zn-Cu couple in THF under nitrogen pressure with ultrasonic agitation. The structure of isolated products was confirmed spectroscopically. On the other hand, the prepared compounds were tested in vitro for their antimicrobial activity against Staphylococcus aurous and Escherichia coli.

Keywords: Reformatsky Reaction, Beta Lactam, Azetidinone, Zn-Cu Coupling, Schiff Base

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doi: 10.23918/eajse.v4i4p148


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