Synthesis and Characterization of Some New Bis-(Dihydropyrimidinones-5-Carboxamide) by Using Ultrasonic Irradiation

Authors: Faiq H.S.Hussain¹ & Havall O. Abdulla^2
1Research Center, Ishik University, Erbil, Iraq
²Department of Chemistry, College of Science, University of Salahaddin, Erbil, Iraq

Abstract:  This investigation involves synthesis of two new series of bis-dihydropyrimidinone-5-carboxamides (4 a-k) and (5 a-k) from reaction of 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetra-hydropyrimidine-5-carbonyl chloride and its derivatives (3 a, b) with different diamines using ultrasonic irradiation. Compounds (3a, b) were synthesized from chlorination of 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid and its derivatives (2a,b) which were prepared from hydrolysis of ethyl-6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimi-dine-5-carbo-xylate and its derivatives (1a, b) which was synthesized by one-pot Biginelli condensation. The synthesized products were characterized by physico-chemical methods such as elemental analysis (CHNS-O), FT-IR, ¹H-NMR and ¹³C-NMR. The prepared compounds were showed biological activity against two types of bacterial Escherichia coli Gram-negative bacteria (G -ve) and Staphylococcus aureas Gram-positive bacteria (G +ve).

Keywords: Dihydropyrimidinone, Biginelli Condensation, Ultrasonic, Hydrolysis, Catalytic Reaction

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doi: 10.23918/eajse.v3i3p132

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