Cytogenetic Study among Chemical Bombardment Survivors in Shekh Wasan & Balisan Valley Kurdistan Region-Iraq

Authors : Hazha Jamal Hidayet¹ & Sheeman Hameed Mohammed^2
1&2Salahaddin University, College of Education, Hawler Medical University-Nursing College, Iraq

Abstract:   This study was performed randomly on 40 individuals selected within a specific period, between January 2014 to October 2014 in order to a certain whether or not a sample of chemical weapons used on Shekh Wasan & Balisan valley in 16 April 1987, have incurred genetic damage. The following results were obtained: The chromosomal aberration is a very sensitive and widely applied assay used as a bio indicator of genetic damage induced by an environmental agent or clastogen. In current study a group of (40) chemical bombardment survivors there were (15) individuals have different types of chromosome aberrations, including (ring chromosome %52.5, dicentric chromosome %30, chromosome break with fragment %57.5, chromatid interchange (quadriradial) %27.5, chromatid interchange (triradial) %27.5.

Keywords: Chromosomal Abberation, Chemical Weapons, Clastogen

doi: 10.23918/eajse.v3i1sip64

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References
Dizaye, K. (2012). Victims of the Long Term Effects of Chemical Weapons on Health in Kurdistan
of Iraq. Middle East Journal of Internal Medicine, 5(4),27-35.
Freshny, G. J. (2008). Cultures of Animal Cells. (3rd Edition). Wiley- Liss. USA.
Genderen, V., Mol, J., & Wolthuis, O. L. (1985). On the development of skin models for toxicity
test. Fund. Appl.Toxicol.5:S98-S111.(Cited from Papirmeister, B. ; Feister, A. J.;
Robinson, s. i. and Ford, R. D.1992)
Gupta, C. R. (2009). Handbook of Toxicology of Chemical Warfare Agents. First edition. Elsevier,
USA.
Herriott, R. M. (1951). Nucleic acid synthesis in mustard gas-related E.coli .B. The Journal
of General Physiology, 34(6), 761-764.
Higginson, J., Muir, C. S., & Munoz, N. (1992). Human cancer: epidemiology and environment
causes. In Cambridge Monographs on Cancer Research. Cambridge University Press,
Cambridge UK. 377-387.
HRW (Human Rights Watch): (1993): GENOCIDE IN IRAQ THE ANFAL Campaign Against the
Kurds, A Middle East Watch Report, Library of Congress Card Catalog Number: 93-
79064, Nework, USA.
Margery, W., & Shaw, M. D. (1970). Human Chromosomal Damage by chemical Agents. Annual
Review of Medicine, 21,409-432.
Mood, B.M., & Hefazi. M. (2005). The pharmacology, Toxicology, and medical treatment of sulfur
mustard poisoning in severely intoxicated Iranain veterans. Fundam. Clin. Pharmacol,19,
713-721.
Papirmeister, B., Feister, A. J., Robinson, S. I., & Ford, R. D. (1992). Medical Defense Against
Mustard Gas Toxic Mechanism & Pharmacologist Implication.P:142. Chapter:6.
Mutagenic and chromosome Damaging.
Roberts, J.J., Pascoe, J.M., Plant, J.M., Sturrock, J. E., & Crathorn, A. R. (1971). Quantitative aspect
of the repair of the alkylated DNA in cultured mammalian cell. The effect of HeLa and
chines hamster survivor of alkylation cellular macromolecule. Chem. Biol. Interact, 3,29-
47.
Scott, D., & Fox, B.W. (1974). The relationship between chromosomal aberrations, survival and
DNA repair in tumour cell lines of differential sensitivity to X-rays and sulphur mustard.
Mutat Res, 22, 207–221.
Sokal. R. R. & Rohlf, J. F.(1987). Introduction to Biostatistics. 2nd edition.P:109.
Sulaiman, K. M. (2013).Genetic variation and long term effects of chemical exposure on the Halabja
population. PH. D. University of Salahaddin. Iraq, Erbil.