Synthesis, Characterization and Antibacterial Activity of Some Metal Complexes of Azo Guanosine and Adenosine Derivatives

Authors :Nahla A. A. Aljabar1 & Ahmed Abdulsattar2
1Knowledge University, College of Science, Department of Pathological Analysis, Erbil, Iraq
2Tikrit University, College of Education, Chemistry Department, Tikrit, Iraq

Abstract:   A series of new coordination complexes of Cu(II), Co(II), Ni(II) with the azo nucleosides derived from the coupling reaction of guanosine and adenosine with substituted phenyl diazonium salts have been prepared .These metal complexes were characterized by elemental analysis, IR, UV-Visible,Conductivity measurement and magnetic susceptibility. It was found that the azo compounds behavesas N,N’-Bidentate donor ligand forming chelates with 1:1 (metal: ligand) stoichiometry. The ligands and their metal complexes have been screened for their antibacterial activity against five species of pathogenic bacteria: Staphylococcus aureus, Streptococcus viridans, Proteus vulgaris, Pseudomonas aeruginosa and Escherichia coli using Disc diffusion method. The activity data had shown that the metal complexes to be more potent antibacterial than the parent azo ligands against one or more bacterial species suggesting that metalation increase the antibacterial activity of those compounds.

Keywords:  Azo Compounds, Metal Complex, Antibacterial

doi: 10.23918/eajse.v3i1sip99

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