Synthesis, Characterization and Antibacterial Activity of Some Metal Complexes of Azo Guanosine and Adenosine Derivatives

Authors :Nahla A. A. Aljabar¹ & Ahmed Abdulsattar^2
1Knowledge University, College of Science, Department of Pathological Analysis, Erbil, Iraq
²Tikrit University, College of Education, Chemistry Department, Tikrit, Iraq

Abstract:   A series of new coordination complexes of Cu(II), Co(II), Ni(II) with the azo nucleosides derived from the coupling reaction of guanosine and adenosine with substituted phenyl diazonium salts have been prepared .These metal complexes were characterized by elemental analysis, IR, UV-Visible,Conductivity measurement and magnetic susceptibility. It was found that the azo compounds behavesas N,N’-Bidentate donor ligand forming chelates with 1:1 (metal: ligand) stoichiometry. The ligands and their metal complexes have been screened for their antibacterial activity against five species of pathogenic bacteria: Staphylococcus aureus, Streptococcus viridans, Proteus vulgaris, Pseudomonas aeruginosa and Escherichia coli using Disc diffusion method. The activity data had shown that the metal complexes to be more potent antibacterial than the parent azo ligands against one or more bacterial species suggesting that metalation increase the antibacterial activity of those compounds.

Keywords:  Azo Compounds, Metal Complex, Antibacterial

doi: 10.23918/eajse.v3i1sip99

Download the PDF Document from here.

References
Addison. C.C., & Gatehouse, B.N. (1960). The Infared Spactra of Analaclrous Transition Metal
Nitrates. J. Chem.Soc., 613.
Banyay, M., Sarkar, M., & Gräslund, A. (2003) A library of IR bands of nucleic acids in solution.
Biophys. Chem. 104,477–488
Bonev, B., Hooper, J., Parisot, J. (2008). “Principles of assessing bacterial susceptibility to
antibiotics using the agar diffusion method. The Journal of antimicrobial chemotherapy, 61
(6), 1295–301. doi:10.1093/jac/dkn090
Buffagni .S., Vallavino. L.M., & Quallon. J.V. (1964). Inorg. Chem., 3, 480
Garg, H.G., & Praksh, C. (1972). Preparation of 4-arylazo-3,5-disubstituted-(2H)-1,2,6-thiadiazine
1,1-dioxides. J. Med. Chem., 15, 435-436.
Garg, H.G., & Praksh, C. (1971). Potential antidiabetics. 7. N1-(β-hydroxybenzylmethyl)-3-methyl4-arylhydrazono-2-pyrazolin-5-ones and N1-(β-hydroxybenzylmethyl)-3-methyl-4-arylazo5-methyl- or -phenylpyrazoles. J. Med. Chem., 14, 175-176.
Hao, J., Han, M.J., Guo, K., Zao, Y., Qiu, L., & Shen, Y. (2008). A novel NLO azothiophene-based
chromophore: Synthesis, characterization, thermal stability and optical nonlinearity, Mater.
Lett., 62, 973-976.
Bailar, J., & Uraban, J. (1973). Comprehensive Inorganic Chemistry. 1st ed., Oxford: Perjamon Press.
Khalid, J., AL-Adilee, K., Abass, A., & Taher, M. (2016). Synthesis of some transition metal
complexes with new heterocyclic thiazolyl azo dye and their uses as sensitizers in photo
reactions. Journal of Molecular Structure,1108, 378-397
Hughes, M., & Rutt,J. (1972) Kinetic and mechanistic studies of the interaction of 2-mercapto
pyridine with dichloro[1-alkyl-2-)imidazole]palladium(II) complexes Dalton Trans.
Chem.Soc. 1311.
Murtaza, G., Rauf, M.K., Badshah, A., Ebihara, M., Said, M., Gielen, M., de Vos, D., Dilshad, E., &
Mirza, B. (2012 )Synthesis, structural characterization and in vitro biological screening of
some homoleptic copper (II) complexes with substituted guanidines. Eur. J. Med. Chem.
48, 26–35. (doi:10.1016/j.ejmech.2011. 11.029)
Nakamoto, K. (1978). Infrared and Raman Spectra of Inorganic and Coordiration Compounals. 2nd edn., John Wiley and Sons.
Parekh, N., Maheria, K., Patel, P., Rathod, M. (2011). Study on antibacterial activity for multidrug
resistance stain by using phenyl pyrazolones substituted 3-amino 1H-pyrazolon (3,4-b)
quinolone derivative in vitro condition. Int. J. Pharm Tech Res., 3, 540-548.
Pavia. D. L., Lampman G. M., Kirz G. S. (2001). Introduction to Spectroscopy”, (3rd edition),
NY:Thomson Learners Inc.
Purohit, K.M., & Vramana, D. (1980). Mixed Chelate Complexes of Copper (II) J.Indian.
Chem.Soc., 57, 363
Ri-Ming, H., Yin-Ning, C., Ziyu, Z., Cheng-Hai, G. Xiangdong, S. & Yan, P. (2014). Marine
Nucleosides: Structure, Bioactivity, Synthesis and Biosynthesis. Mar. Drugs, 12, 5817-
5838; doi:10.3390/md12125817
Saha, S., Majumdar, T., & Mahapatra, A. (2006). Kinetic and mechanistic studies of the interaction
of 2-mercapto pyridine with dichloro [1-alkyl-2-(arylazo) imidazole] palladium(II)
Transition Metal Chemistry, 31(8), 1017–1023
Silverstein. R. M., & Webster, F. (1999). F. X, Spectrometric Identification of Organic Compounds,
6th Ed. John Wiley & Sons, Inc.